Known for his physical power, Kuffour is best remembered for his time with Bayern Munich, whom he represented for over a decade, winning a total of 14 honours, and playing in nearly 250 official matches.

Born in Ghana, Kuffour was brought to Europe by Torino FC in 1991 aged just 15, after playing junior football for local teams in his native country.

Kuffour spent 11 seasons with Bayern, rising from the youth teams to be a prominent first-squad member who lifted the UEFA Champions League with the club.

He was an integral part of the squad that won the 2000–01 Champions League, also scoring the winning goal in the 2001 Intercontinental Cup, being subsequently named man of the match.

He also became the youngest defender to ever score in the Champions League, at the age of 18 years and 61 days, during the match against Spartak Moscow on 2 November 1994, which ended in a 2–2 draw.

[11] Kuffour rejected the news and stated his desire to continue his career; in January 2009, he was linked to Major League Soccer side Chicago Fire S.C. – the CEO of US-based Sports to Develop Destitute claimed he was helping the player finalise the deal.

In the interview, he also spoke about the surprised reaction of some German players as he prayed before games, while also addressing the support he received from fellow Ghanaian Christians, especially those living in Munich.

[15] He is also the father of aspiring young footballer Samuel Kuffour Jr, who recently signed for Hapoel Be'er Sheva.

[17][18] On 8 February 2015, he was shaved as he vowed on live TV within the SupersSports studios following the Black Stars failure to win the AFCON 2015 as he predicted.

[21][22] On 2 October 2014, whilst serving as a board member, he was announced as the new CEO for Kumasi Asante Kotoko after being appointed by the club owner Otumfuo Nana Osei Tutu II.