It was established in 1878 by Mrs Mary Ann Swainson as a day and boarding school for girls from Wellington and the surrounding areas.

In January 2022 Paula Wells became Samuel Marsden Collegiate School's 13th Principal taking over from Narelle Umbers who returned to Melbourne after 4 years in the role.

Samuel Marsden Collegiate School students complete the New Zealand National Certificate of Educational Achievement (NCEA).

Marsden Whitby's houses bear no relation to the long history of the Karori school.

Instead carrying the nautical theme that the suburb of Whitby is known for – Endeavour, Resolution, Discovery and Adventure.