By 1623 he was a member of the Virginia Governor's Council and was actively involved in conflicts with the Native Americans, leading a force against the Tanx (Weyanoke) Powhatan Indians.
Frances Grevill was one of four women who arrived at Jamestown from Bristol, England in September 1620 aboard the ship, Supply.
After West's death 24 February 1623, Grevill married Abraham Peirsey, a wealthy man who had purchased Sir George Yeardley's Flowerdew Hundred Plantation.
[4] In later life, Mathews would return to England to serve in London as the Colony's representative in handling disputes, particularly in the matter of establishing the border with Maryland.
As a member of the House of Burgesses, Mathews was viewed as an "honest, energetic and faithful servant of the Colony" whose death was "universally lamented.