Samuel Medary (February 25, 1801 – November 7, 1864) was an American newspaper owner and politician.

Born and raised in Montgomery County, Pennsylvania, he settled in Bethel, Ohio, in 1825.

He was active at the National Democratic Conventions at Baltimore in 1844, where he was instrumental in the nomination of James K. Polk; and at Cincinnati in 1856, where he was the President pro tem.

President James Buchanan appointed him as the third Territorial Governor of Minnesota from April 23, 1857, to May 24, 1858.

Medary was indicted by a federal grand jury in 1864 for conspiracy against the government and was arrested.