Born in Bullitt County, Kentucky, Peyton completed preparatory studies.

He was graduated from the medical department of Transylvania University, Lexington, Kentucky, in 1827 and began practice in Hartford, Kentucky.

He served as member of the Kentucky House of Representatives in 1835.

He was an unsuccessful candidate for reelection in 1848 to the Thirty-first Congress.

[citation needed] This article incorporates public domain material from the Biographical Directory of the United States Congress