Samuel Sitgreaves (March 16, 1764 – April 4, 1827) was a United States representative from Pennsylvania during the late 18th century.

Sitgreaves was a delegate to the Pennsylvania Constitutional Convention in 1790, and was elected as a Federalist to the Fourth and Fifth Congresses, serving from March 4, 1795, until his resignation in 1798.

On August 11, 1798, Sitgreaves was appointed United States commissioner to Great Britain under the Jay Treaty, regarding British debt claims arising from the American Revolution.

After his involvement in the Blount affair of 1797, Sitgreaves was considered the Congressional expert on treason.

Sitgreaves was successful in his prosecution and the jury in the case found the men guilty of treason, but a second trial and an eventual pardon from President John Adams saved the rebels from execution.