Built in 1835, it is one of the city's best-preserved examples of Greek Revival architecture, and was home to a prominent businessman and educator.

A two-story ell was added onto the north (rear) end of the house, and modified in 1938 to accommodate a garage in its basement area.

The interior retains original features, including wide flooring, Greek Revival fireplace surrounds, and door and window hardware.

Samuel Wyatt was owner of several hotels, including one nearby in Dover, and Sophia was a prominent local teacher and author.

Sophia Wyatt was also active in early efforts to provide increased educational opportunities for girls and women.