The Samwell Baronetcy, of Upton in the County of Northampton, was a title in the Baronetage of England.

It was created on 22 December 1675 Thomas Samwell, later Member of Parliament for Northamptonshire and Northampton.

He was the great-grandson of Sir William Samwell, Auditor of the Exchequer to Queen Elizabeth I of England.

The second Baronet sat as Member of Parliament for Coventry.

On the death of the fourth Baronet in 1789, the title became extinct.