[3] In 2005, he created and released the fastest spreading virus of all time,[4] the MySpace worm Samy, and was subsequently raided by the United States Secret Service under the Patriot Act.

In 2006, Kamkar was raided by the United States Secret Service and Electronic Crimes Task Force, expanded from the Patriot Act, for releasing the worm.

[5] After being presented with a plea bargain for no prison time, but paying a fine of US$20,000, serving three years of probation, working 720 hours of community service, Kamkar pled guilty to a felony charge of computer hacking in Los Angeles Superior Court.

[20][21][22] In late 2010, Kamkar traveled to Bratislava to attend Faraday Hack Day to help expose political and corporate corruption within Slovakia's government.

[23][failed verification] In early 2011, Kamkar joined the Board of Directors of Brave New Software,[24] a non-profit organization originally funded by a multimillion-dollar U.S. State Department grant.

[25] The nonprofit is responsible for creating uProxy with the University of Washington and Google Ideas, a browser extension intended to allow users in repressive regimes to access the Internet without being monitored.

The nonprofit also created Lantern, a network designed to circumvent Internet censorship and defeat the suppression of digital information and freedom of speech.

In 2011, Kamkar discovered the iPhone, Android and Windows Phone mobile devices were continuously sending GPS coordinates, correlated to Wi-Fi MAC addresses, back to Apple, Google and Microsoft respectively, and released his research through several front page The Wall Street Journal articles.

[41][42] The software was released one day after Amazon.com announced Amazon Prime Air, a possible future delivery service using drones to deliver small packages in as early as 2015.

On November 16, 2016, Samy Kamkar released PoisonTap;[48] a USB Ethernet emulator that can be used to hijack all Internet traffic on a target machine, even if the computer was password protected and locked.