[2] On 16 June 2013, Samy Sana won the Wicked One Tournament in the 70 kg light middleweight division by defeating Guimba Coulibaly by knockout and Kevin Renahy by decision in one night.

[citation needed] At the "Best of Siam" event held at Rajadamnern Stadium on 27 May 2016, Sana defeated Eakchanachai Kaewsamrit via third-round knockout to win the WBC Muaythai World Super Middleweight (75 kg) Championship.

[4] Samy Sana defeated Fernando Calzetta at the joint event between Oktagon and Bellator on 9 December 2017 to win the ISKA Muay Thai World Middleweight (72.5 kg) Championship.

[citation needed] On 17 March 2018, Samy Sana defeated both Kevin Renahy and Zakaria Laaouatni in the same night in Tours, France to win the "La Nuit Des Titans" 72.5 kg middleweight tournament.

Sana was announced as one of the participants in the ONE Super Series Featherweight Kickboxing World Grand Prix, which included Giorgio Petrosyan, Yodsanklai Fairtex, and Phetmorakot Petchyindee Academy.