It is located on the coast, at the foot of the Anaga mountains, 7 km (4.3 mi) northeast of the capital city Santa Cruz de Tenerife.

[3] From 1505–1510 Don Lope, built the chapel, on which the current church is based, and he placed two images: St. Andrew the Apostle, by special devotion, and Saint Lucy, in honor of the name of his wife.

Until the construction of the defensive castle, the village had acquired the reputation of a "pirate port" because the place was used as a landing stage for the numerous robber ships that frequented the waters of the Canary Islands at this time.

[4] In 1797 San Andrés will participate in the defense of the island in front of the attack of Admiral Horatio Nelson, by sending militiamen of the village to the port of Santa Cruz and by avoiding with its castle the assault of the English on this part of the coast.

During the Civil War and the postwar period, San Andrés lives moments of hard repression and becomes in place of adjustment of the contrary to the Franco regime.

In nearby Macizo de Anaga one finds the zone of "El Bailadero", so named because, according to the old legends, it was the place where witches danced around bonfires and practiced witchcraft.