San Andrés Itzapa has several heavily forested areas, which include eucalyptus, poplars, pines, holly, oaks, cypress and other evergreen and deciduous species.

Plants found in San Andrés Itzapa include canaque, casuarina, conacaste, hormigo, grabilea and palo blanco, as well as varieties of aloe.

Animals include coyote, armadillos, mountain lions, tisote, lynxes, goyoy, kinkajou, squirrels, racoons, wild boars, dove, cayayes, pajuil, and pheasant.

Wheat, cotton, corn, beans, avocado, chayote, beet, radish, squash, carrot, broccoli, cabbage, coffee and guaque Chile peppers are grown.

The municipality is rich in the craftsmanship of leather goods such as knife and machete sheaths, sandals, articles of jade, tables and chairs, ropemaking, and others.