San Andrés Zautla is a town and municipality in Oaxaca in south-western Mexico.

It is part of the Etla District in the Valles Centrales region.

As of 2005, the municipality had a total population of 5,326, of whom 281 spoke an indigenous language.

[1] During the colonial period San Andrés Zautla was part of the jurisdiction of Huexolotitlan.

[2] A 16th century Spanish colonial church in town is a listed Cultural Landmark, and possesses a historic pipe organ, dated 1726, now restored and playable.