San Antonio is a municipality in the Honduran department of Intibucá.

At the time of the 2013 Honduras census, San Antonio municipality had a population of 5,492.

Of these, 72.67% were Mestizo, 18.07% Indigenous (17.99% Lenca), 5.30% White, 2.90% Black or Afro-Honduran and 1.06% others.

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