San Antonio Huista is a town and municipality in the Guatemalan department of Huehuetenango.

It is located 362 kilometers from Guatemala City.

The predominant language is Spanish, while approximately 20% of the population speak indigenous languages, the majority speaking Mam.

The municipality of San Antonio Huista is situated at 1240 metres above sea level, with a population of 16,697 (2018 census).

The annual festival is December 8–12 dedicated to the Virgin of Guadalupe and the patron saint's day (Saint Anthony of Padua) is celebrated June 11–13.