San Cristóbal Acasaguastlán (Spanish pronunciation: [saŋ kɾisˈtoβal akasaɣwaskaˈtlan]) is a town in the El Progreso department of Guatemala.

San Cristóbal Acasaguastlán is located on the northern bank of the Motagua River at an altitude of 250 m. It had a population of 6,129 people at the 2002 census,[1] and covers a territory of 124 square kilometres (48 sq mi).

In the ninth and tenth centuries AD, the Nahuas settled in the vicinity of San Cristóbal Acasaguastlán, beginning a cultural mixture leading to their indigenous language (Alaguilac).

The Spanish used the prehistoric Acasaguastlán province for their town of San Cristobal; its central square was the site for one of the pro-independence riots of 1812.

After Guatemala gained its independence from Spain in 1821, San Cristóbal Acasaguastlán belonged to the Zacapa Department under Decree 683 of April 13, 1908; with Legislative Decree 1965 of April 3, 1934 the new Department of El Progreso was established, which included San Cristóbal Acasaguastlán.