It is located northwest of Gainesville, Florida on CR 232 (Millhopper Road), just south of the town of Alachua.

Among the wildlife of the park are feral pigs, bobcats, white-tailed deer, gray foxes, wild turkeys, and many species of songbirds.

[1] The park includes 56 archaeological sites, representing various eras from the Paleo-Indian period (10,000 to 12,000 years ago) up to the 20th century.

The site of the Spanish-era Mission San Francisco de Potano, on the U.S. National Register of Historic Places, is in the park.

Sites in the park from the 20th century include remains of moonshine stills, a dairy farm, tung oil operations, and a commune.