Despite this victory over the fleet of commodore Charles Knowles, the Spanish continued to strengthen the fortifications of Puerto Cabello and built another fort, Solano Castle, above the town.

In 1822, the Marechal Francisco Tomás Morales assumed the supreme command of the forces of Puerto Cabello and Sebastian de la Calzada brigadier was appointed deputy chief.

As of August 3, 1823 as a result of the capitulation of Morales to the Republicans in Maracaibo, Calzada remained as the last commander of the fort, a position he held until 10 November of the same year when he surrendered his forces to the Venezuelan caudillo José Antonio Páez.

In 1962, Puerto Cabello was the site of an uprising, known as El Porteñazo, by pro-Fidel Castro naval officers, marines, and members of the FALN.

Despite ambushes and bloody house-to-house fighting, loyal National Guard and mechanized regular forces were able to retake Puerto Cabello.