San Francisco University High School is a private college preparatory high school located in San Francisco, California.

[1] The school is made up of four buildings, commonly referred to as Upper, Middle, Lower, and South campuses.

Middle Campus, connected to Upper Campus by a bridge, houses the school library; a 400-seat theater; the student center and cafeteria; state-of-the-art science labs; music rooms, including an electronic music recording room; and the Summerbridge program, UHS's pioneer program to help talented students from local public middle schools obtain the resources they might not have access to in their current schools.

It also holds the fitness center, changing rooms, gym, and athletic offices.

There was an investigation in 2021 into improper conduct between adults and students at the high school, involving, in particular, a former girls’ soccer coach.