[3] The district includes numerous homes, among these the noted Victorian-style Juan Ortiz Perichi House on Luna Street, which architect Jorge Rigau once called "one of the best developed spatial sequences in residential architecture in Puerto Rico."

Many notable Puerto Ricans came from the San Germán Historic District; among them was Lola Rodríguez de Tió, the well-known poet and pro-independence leader who wrote the lyrics to the revolutionary version of Puerto Rico's national anthem "La Borinqueña".

In late summer 1898, under the command of General Theodore Schwan, the United States Cavalry traveled through Luna Street, during the Spanish-American War, and Puerto Ricans welcomed the Americans in this district and in nearby Mayagüez, with flowers- believing in the promise of prosperity that would come under American rule.

Despite wanting to spend the night in San Germán, the Americans decided to continue moving on, to battle the Spanish.

[4][5] The San Germán Historic District is roughly bounded by Luna, Estrella, Concepción, Javilla, and Ferrocarril Streets in the western section of the town.