It is located near present-day San Ignacio valley, some 60 kilometers (37 mi) north of Posadas, Misiones Province, Argentina.

[1] The original mission was erected near the year 1610 by Jesuit priests José Cataldino and Simón Maceta in the region called Guayrá by the natives and La Pinería by the Spanish conquistadores in present Paraná State, Brazil.

They produced rich cultural and handicraft products, which the Spanish commercialized by trade via the nearby Paraná River.

Overgrown by dense vegetation, the remains of the mission, built in the "Guaraní baroque" style, were found in 1897.

The site is the location of the Museo Jesuítico de San Ignacio Miní museum, constructed after the international recognition.