[5] After the first cry against the Spanish colonial government was made in 1896, there were 2,000 revolutionary soldiers under General Mariano Llanera who sieged San Isidro.

General Frederick Funston planned the capture of Aguinaldo to end the Philippine–American War, in San Isidro.

[citation needed] On September 11, 1989, Mayor Enrique Lorenzo was on his way back from Manila to San Isidro with his wife Aurora, their driver and one of their security personnel when they were ambushed by four gunmen along the Sta.

Poverty Incidence of San Isidro Source: Philippine Statistics Authority[13][14][15][16][17][18][19][20] Primarily depends on rice & vegetable farming, poultry and piggery.

As of 2017, based on Commission on Audit of the Philippines, San Isidro reached their income of ₱129,676,820.86; assets of ₱494,469,351.35; liabilities of ₱229,800,110.14 and allotments of ₱135,154,456.00.