[1] The relief of San Jorge presents a contrast between the flat plains in the northern and western parts of the municipality, and the mountainous terrain punctuated by steep valleys in the east and south.

The longest of these is the Quebrada San Juan, which flows 24 kilometres (15 mi) southwest to northeast from the El Gigante mountain to the Río Grande de Zacapa.

As in the rest of Zacapa Department, rainfall is low and highly variable: annual precipitation is 470 millimetres (19 in), and the wet season lasts from June to October.

[2] On 28 January 2014, the Congress of the Republic of Guatemala decreed the creation of San Jorge from territory previously part of the municipality of Zacapa.

[4] Holy Week festivities in San Jorge include parades, the making of sawdust carpets, and traditional cuisine and dancing.

[2] A paved departmental road ZAC-8 connects the municipal seat of San Jorge with Central America Highway 10 just outside of the town of Zacapa.