San José is a small town in the Santa Cruz Department in the South American Andean Republic of Bolivia.

San José is the central town of Cantón San José and is located in La Guardia Municipality in Andrés Ibáñez Province.

It is situated on the right banks of Río Piraí at an elevation of 507 m, south of the nearest town, La Guardia, and north of Santa Rita.

San José is located 26 kilometers south-west of the departmental capital Santa Cruz.

From there, Ruta 7 goes on to La Angostura, Samaipata, Comarapa and Cochabamba.