[2] The station was designed by Félix Candela[3] and consists of interlocked hyperbolic paraboloidal or saddle roof sections.

San Lázaro was the main terminus for the Interoceanic Railway, which linked the port of Veracruz, on the Gulf of Mexico, with the Pacific Ocean.

Nearby is the building that houses the Chamber of Deputies ("Palacio Legislativo" in Spanish), the lower house of the Mexican Congress (Congreso de la Unión).

[6] This bus station serves states including Puebla, Veracruz, Oaxaca, and Yucatán.

It is used by some of the most prestigious and safest bus lines in Mexico, such as ADO, UNO, and Maya de Oro.