San Lorenzo affiliated to the Argentine Association in the 1930s decade, and won a large number of championships from the 1930s to the 1970s, being nicknamed The Cathedral of Basketball.

1942 was the year when San Lorenzo achieved its first titles, winning the Torneo Apertura (Opening Tournament) and the Official championship, organised by the Buenos Aires Basketball Association.

In 1966, San Lorenzo won the Apertura title finishing unbeaten, and both the Metropolitano and Buenos Aires championships, in 1968.

San Lorenzo defeated OKK Beograd, Yugoslavian national league club, and six rivals from Italy.

In 2014, San Lorenzo debuted in the Torneo Nacional de Ascenso (TNA) (National Promotion Tournament), the second tier level division of professional basketball in Argentina.

[7] 30 years after its debut in the LNB, San Lorenzo returned to the top division on September 22, 2015, and beat Quimsa, by a score of 79–64.

[8] San Lorenzo won its first LNB title in 2016, after beating La Unión, with a 4–0 series sweep in the league's finals.

[9] In the following season, San Lorenzo won its 2nd consecutive Argentine League title, after defeating Regatas Corrientes, 4–1 at the finals.

[10] Unlike the 2015–16 series, San Lorenzo played its home games at Roberto Pando arena, in Boedo, Buenos Aires.

[11] San Lorenzo plays its home games at the Polideportivo Roberto Pando, which is located in Boedo, Buenos Aires.