The San Luis Obispo Handicap is an American Thoroughbred horse race held annually at Santa Anita Park in Arcadia, California.
A Grade II event, it offers a purse of $150,000.
Inaugurated as the Washington's Birthday Handicap in 1950, it was run on dirt until 1954 when it became a turf race.
There was no race from 1963 through 1967 but returned in 1968 as the San Luis Obispo Handicap, named for the city of San Luis Obispo further up the Central Coast of California from Santa Anita Park.
Since inception it has been contested at various distances: The San Luis Obispo Handicap was run in two divisions in 1968, 1972, and 1974.