San Luis Río Colorado is a city and also the name of its surrounding municipality in the state of Sonora, Mexico.

Lying in the northwestern corner of Sonora, the city marks the state border with Baja California.

Awarded city status in July 1958, San Luis Río Colorado serves as the administrative center for the surrounding municipality of the same name.

The Sears department store (formerly Dorian's) and 5 schools were destroyed, affecting approximately 30,000 people in the region.

Josse, a Mexican Latin beat singer recorded a song called "San Luis Río Colorado" as a tribute to the river.