It opened in 1996, replacing Fiscalini Field as the home park of Minor League Baseball's Inland Empire 66ers of San Bernardino.

It is located directly next to the San Bernardino Transit Center, with connections to Los Angeles Union Station.

In 2004, it also served as the home of the Los Angeles Unity, the city's Pro Cricket team.

In 2010, San Manuel Stadium was equipped with a new scoreboard, which was the largest in the California League.

[3] In 2010, CSUSB moved its home games to Fiscalini Field, San Bernardino's former minor league stadium.