San Marcos de Caiquín is a municipality in the Honduran department of Lempira created November 4, 1994.

The "Lenca" community of San Marcos de Caiquin has historically been a village of La Campa municipality.

Because of their cultural and economical activities, they decided to create a municipality with its own ethnic traits.

The forests provide a profitable economical activity, best of all is that the people have ecological conscience and make the most out them.

At the time of the 2013 Honduras census, San Marcos de Caiquín municipality had a population of 5,571.