The San Marino national under-21 football team represents the under-21s of San Marino in the UEFA U-21 Championship, and is controlled by the San Marino Football Federation (FSGC, Italian: Federazione Sammarinese Giuoco Calcio), the governing body of football of the state.

In the 2004 qualifying they lost 6–0 to Sweden but UEFA later awarded the match as a 3–0 forfeit win to San Marino due to Sweden including suspended players in their squad.

In the preliminary round of the 2007 qualifying they lost 2–1 to Armenia but UEFA also awarded the match as a 3–0 forfeit win for San Marino.

In June 2012, they held Greece to a goalless draw in the 2013 qualifying.

On 6 September 2013, San Marino recorded their first competitive win 1–0 over Wales at Stadio Olimpico in the 2015 qualifying.