San Miguel Amatitlán is a town and municipality in Oaxaca in south-western Mexico.

The municipality covers an area of 198.48 km².

It is part of the Huajuapan District in the north of the Mixteca Region.

As of 2005, the municipality had a total population of 5,938.

This article about a location in the Mexican state of Oaxaca is a stub.