42°38′52.0″N 12°29′1.2″E / 42.647778°N 12.483667°E / 42.647778; 12.483667San Nicolò is a Roman Catholic church located in the town of Montecastrilli, in the province of Terni, region of Umbria, Italy.
The present church with a Latin cross layout houses a Last Supper (1602) by Archita Ricci da Urbino.
Thirteen panels in the chapel of the Holiest Rosary are attributed to Andrea Polinori; two are nineteenth century works.
The chapel houses a Madonna of the Rosary (1606) also by Ricci.
The left transept houses a painting of the Madonna of the "Refugium Peccatorum" (late 1500s) transferred here from the suppressed parish church of Castelfranco.