Established in 1786 at the Ohlone village of Pruristac, the site is located within the bounds of the Rancho San Pedro (home to the Sánchez Adobe).

Crops of wheat and beans were planted and limestone was mined at nearby Mori Point in quantities to provide for the food and construction needs of the parent mission.

Corn, peas, barley, asparagus, and rosemary would, in time also be cultivated, along with grape vineyards and groves of peach and quince trees.

After secularization of the missions in 1834, Juan Alvarado, the Mexican Governor of California, granted the lands of the 8,926-acre (36.12 km2) Rancho San Pedro to Francisco Sanchez in 1839.

In 1894, roof tiles were salvaged from the property and installed on the Southern Pacific Railroad depot located in Burlingame, California (the first permanent structure constructed in the Mission Revival Style).