San Sebastián del Oeste (Spanish: [san seβasˈtjan del oˈeste] ⓘ) is a town and municipality, located on the western part of Jalisco state, Mexico, between 20°39’45’’ - 21°02’30’’ N and 104°35’00’’ - 104°51’00’’ W, at a height of 1,480 metres (4,856 ft).

San Sebastián was founded as a mining town in 1605, during the early Spanish colonial Viceroyalty of New Spain period.

San Sebastián del Oeste is a designated Pueblo Mágico, one of the towns maintaining their historical character and promoted by the federal government as tourism destinations.

It also receives tourists visiting nearby Puerto Vallarta on the coast to the west.

Recent road improvements reduced transit time from Puerto Vallarta to under 2 hours.