San Vicente del Caguán (Spanish pronunciation: [sam biˈsente ðel kaˈɣwan]) is a town and municipality in Amazonian Caquetá Department, southern Colombia.

Its Marian Catedral Nuestra Señora de las Mercedes (dedicated to the Virgin of Mercy) is the cathedral episcopal see of the Roman Catholic Diocese of San Vicente del Caguán.

Between 1998 and 2002, San Vicente del Caguán was the center of the demilitarized zone (DMZ), which was created as a safe haven for the revolutionary FARC rebels.

Two days after the peace talks were ended, Ingrid Betancourt was kidnapped while entering the former DMZ.

This Caquetá Department location article is a stub.