San Zenone degli Ezzelini borders the following municipalities: Borso del Grappa, Pieve del Grappa, Fonte, Loria, Mussolente, and Riese Pio X. San Zenone's territory was inhabited since prehistoric times, as attested by archaeological excavations that found stone utensils like scrapers and guns dated back to the Neolithic (5.000-2.500 BC).

It was hypothesized the establishment of a factory that realized similar objects and that the area surrounding Asolo hosted the most important human settlements, whereas the underlying plan wasn't populated due to the presence of forests.

Initially, it depended from the pieve of Sant'Eulalia, actually a fraction of the commune of Borso del Grappa, but around the 10th century it should have assumed the ecclesiastical authonomy.

In fact, a plebem S. Zenonis cum medietate castri et pertinentiis suis was mentioned in a Latin list of the possessions of the bishop of Treviso dated back to 1152.

His dominion broke up rapidly and Alberico, the Ezzelino's son and most important ally, took refuge in the San Zenone's castle: here, after a long siege of a league of Guelph cities, he was captured by his enemies and killed together with his family the following year.

Except for the War of the League of Cambrai, the Venetian rulig created a period of political stability and economical prosperity for the local population.