Sancti-Spiritus is a municipality in the province of Salamanca, in the autonomous community of Castile-Leon, Spain.

It is 70 km away from Salamanca, the capital of the province.

The area of the municipality is 142 km2 and it ranks 4th among the municipalities in the provinces of Salamanca after Ciudad Rodrigo, Castillejo de Martín Viejo, and Ledesma.

As of 2016 its population is 854 inhabitants and the postal code 37470.

This article about a location in the province of Salamanca, Spain, is a stub.