Groen is known for being the doubles partner of many top-5 singles players like Pat Cash, Goran Ivanišević, Gustavo Kuerten, Marcelo Ríos, Marat Safin, Magnus Norman, Greg Rusedski, Alex Corretja, Marc Rosset and Roger Federer.

Federer won his first-ever professional title on the tour playing together with Groen in Segovia 1999.

Groen recorded doubles wins over Federer, Safin, Rios, Patrick Rafter and world number 1 teams Eltingh/ Haarhuis (with Fredrik Bergh), Bhupathi/ Paes (with Jan Siemerink and with Andrei Pavel) and Knowles/ Nestor (with Laurence Tieleman) In singles Groen qualified for 9 ATP Tour events reaching the second round in 3 events and he recorded wins over Tim Henman, Richard Krajicek Felix Mantilla and Andrei Chesnokov.

He won the dutch national masters in 1992 beating Fernon Wibier in the finals and was runner-up to Jan Siemerink in 1994.

In 2004 Sander Groen made his mark on the ITF senior tour by winning the men's singles over 35 world championships followed by finishing runner-up in 2005 and 2006.