"(...) the young female protagonist, Wendla Bergmann, is played by the deaf Sandra Mae Frank, who uses sign language to deliver her lines"[8] Director Michael Arden said "Frank has developed Wendla into a character with more depth and understanding of a girl living in the late 19th century."
[13] In 2019, Frank appeared as Amy in the science-fiction film Multiverse as a member of a group of students who experiment with the connections between different versions of the universe.
[15] Frank had a guest appearance as the deaf student Abigail in the show Zoey's Extraordinary Playlist, in episode 9 of the first season, where she sign-singing interpreted Rachel Platten's "Fight Song" in ASL, while the voice is replaced by a cello.
[16][17] In 2021, Frank entered the NBC TV show New Amsterdam at the beginning of season 4, joining the team of Dr. Goodwin (Ryan Eggold) in the role of deaf oncologist Dr. Elizabeth Wilder.
She performed the ASL synchronization of the US national anthem and "America the Beautiful" at the 2022 56th Super Bowl in Inglewood, California.
[24] "The fact that a production as ambitious as this works and runs so smoothly is due to the two directors Baron and Frank.
[27] Frank was cast in 2022 for the 2023 film The Silent Hour in the role of Ava, co-starring with Joel Kinnaman, Mekhi Phifer and Mark Strong.