Brétigny began her career with FC Lyon and remained with the club during it transformation to Olympique Lyonnais.

Despite having solid seasons with Lyon previously, including leading the league in goals scored in 2003, it wasn't until the 2006–07 season where she gained recognition for being a feared striker when she scored 48 goals in 25 matches helping the club win their first title under the Olympique Lyonnais emblem.

She would proceed to accomplish this feat again on 9 November 2008 in a match against FCF Hénin-Beaumont, though the final result was lowered to an 8–0 victory.

She was the only player to remain from the squad of FC Lyon when, in 2003, the club was transformed to Olympique Lyonnais.

Despite having some individual success earlier in her career, Brétigny made her international debut for the Bleues on 22 November 2006 in a match against Belgium.