Sandro was already signed to Tottenham through most of the competition, but that did not affect his performance negatively: on the contrary, he said he "live[d] with great intensity, as each game could be the last".

[6] However, on 20 October 2009, Spurs and Internacional agreed an affiliation of the two clubs, ensuring that Tottenham have first option on all academy players from the Brazilian outfit.

[11] Tottenham Hotspur confirmed that a deal for Sandro had been completed and that he would join up at the end of Internacional's Copa Libertadores campaign.

On 9 January 2011, Sandro made a start against League One side Charlton Athletic, assisting Andros Townsend and playing the full match.

He made his UEFA Champions League debut for Tottenham on 15 February 2011 at the San Siro against seven times winners A.C. Milan, receiving special praise from manager Harry Redknapp in his side's 1–0 win.

Playing a pivotal role just in front of the back four, he was man of the match in the return leg at White Hart Lane.

He scored his third goal in Tottenham colours in December 2013 against Manchester United, with a powerful shot from 25 yards (23 m) into the top corner described by opponent Wayne Rooney as "a great strike".

[31] On 5 November 2024, Harborough Town of the Southern League Premier Central announced that Sandro had signed a contract with the club.

[32] He was convinced by Harborough Town manager Mitch Austin after meeting him at a Tottenham Hotspur game and was jokingly offered a chance to play for the club.