In 1961, he started the musical group Sandro & los de Fuego, which gained popularity on the TV show Sábados Circulares, and became widely known in the 1960s.

Sandro also had the leading role in 11 films, including Quiero llenarme de ti ("I Want to Fill Myself with You" – 1969) and Subí que te llevo ("Hop On, I'll Give You a Ride" – 1980), and directed one feature, Tú me enloqueces ("You Drive Me Crazy"), in 1976.

Sandro was the first Latino singer to sell out the Felt Forum at Madison Square Garden in New York City (its top capacity being 5,000) five times during the 1970s.

Sandro continued releasing studio albums in the early 1990s and reappeared on stage in 1993 with a new show, that was presented at Teatro Gran Rex, a prestigious popular music venue in Buenos Aires, performing 18 attendance-record-breaking consecutive concerts.

Five days later, in a daily press conference held by his doctors, it was reported that Sandro, although still in intensive care, was breathing without a respirator and that he had started a slow recovery.

Nevertheless, on the evening of January 4, 2010, 45 days after receiving the transplant and after many complications, he died of septic shock, mesenteric ischemia, and disseminated intravascular coagulation in the Hospital Italiano of Mendoza.