The Sanford Coyote Sports Center is an indoor arena located on the campus of the University of South Dakota (USD) in Vermillion, South Dakota.

[1] The center is named after a major supporter of the athletic program, Sanford Health, which donated $20 million to help with construction of the facility.

[2] The facility is connected to the DakotaDome, which had previously been home to all of the new arena's main tenants and remains home to Coyote football, track & field, and swimming & diving.

In addition to the main arena, it houses athletic department offices, training and meeting facilities, two practice courts, a video production room that controls display boards at all USD sports venues, and an area set aside for future expansion of the USD occupational and physical therapy programs.

Additionally, it includes luxury boxes that allow their fans to watch events at both the Sanford Coyote Sports Center and DakotaDome.