The Sangre de Cristo Wilderness is a long and narrow wilderness area covering 220,803 acres (893.56 km2) of the Sangre de Cristo Range centered about Saguache and Custer counties, Colorado.

Smaller areas are located in Fremont, Alamosa, and Huerfano counties.

This wilderness is home to black bears, cougars, elk, and bighorn sheep.

The Peaks had traditional and religious significance to the region's early Spanish settlers, hence the name, which means "Blood of Christ".

The faulted and uplifted mountains of the Sangre de Cristo are geologically distinct from the Spanish Peaks range to the east.