The college is a part of the world-wide network of Seventh-day Adventist (SDA) institutions of higher education, the world's second largest Christian school system.

[4][5][6][7] The history of the college began in 1898 when William C. Grainger, an SDA missionary, founded Shiba Bible School (芝和英聖書学校, Shiba waei seisho gakkō)[8] in Azabu, Tokyo.

In 1926 the school was moved to Sodegaura, Chiba and renamed Nihon San’iku Gakuin.

The name San’iku (三育), combination of 三 (san, 'three') and 育 (iku, 'to nourish, to bring up'), means 'to make people whole' in physical (corpus), intellectual (mens) and spiritual (spiritus) attributes.

After a one-year clinical study in Tokyo,[12] they move to Otaki Campus again.