[1][2] The film stars John Glover, David Mazouz, and Lou Diamond Phillips as three people whose stories ultimately lead them - and friends - to become patients of a sanitarium.

A young boy, Steven, who has catatonic schizophrenia, lives with his abusive father, who forces him to do household chores while he goes to a stripper club every day.

Suspecting that his father is abusive after seeing him rudely fetch Steven home while refusing to explain his neck bruise (actually caused by the monstrous man), she trails them.

Presented in an anachronistic order, the segment tells the story of a college professor called James Silo, who is also an avid conspiracy theorist of the 2012 doomsday event.

He believes that on 21 December 2012, the planet Nibiru will collide with the Earth and to protect himself and his family, he builds a bunker underground, containing a small bedroom and working room, hydroponic culture to sustain food, and a heater.

Throughout the segment, it became apparent that James' obsession had distanced himself from reality; his students began to leave his class until no one was left, dismissing him from his university.

Eventually, Allison decided to call the staff from the sanitarium to confine James, yet he managed to escape and began to live in the bunker for over 640 days, believing that he was the last man left and that his family was dead.

Valderrama experienced some difficulty while shooting his segment, Up to the Last Man, as the filming location was on "the second story of a warehouse in between a highway and a train station, in July, with no air conditioning.

[5] The movie received praise from Ain't It Cool News, who wrote that the anthology was "a pretty good one" but expressed some frustration that the dialogue from the mental health physicians was not entirely accurate to how they spoke to patients in real life but also noted that this was a common problem in cinema.