The Sanjak of Drama (Ottoman Turkish: Sancak-i/Liva-i Drama; Greek: λιβάς/σαντζάκι Δράμας) was a second-level Ottoman province (sanjak or liva) encompassing the region around the town of Drama (now in Greece) in eastern Macedonia.

The sanjak was formed as part of the Tanzimat reforms ca.

1846, from territory taken from various provinces; Drama itself belonged to the Sanjak of Siroz.

In 1891, its territories east of the Nestos river became part of the Sanjak of Adrianople.

In 1912, the sanjak comprised six sub-provinces (kazas): Drama, Kavala, Sarışaban (Chrysoupoli), the island of Taşuz (Thasos) and Pravişte (Eleftheroupolis).