Sans Souci is a historic home located at Hillsborough, Orange County, North Carolina.

It was built about 1813, as two-story, three-bay, frame dwelling with a gable roof and set on a brick foundation.

Later additions included 1+1⁄2-story flanking wings added in the Federal period and a Greek Revival shed addition built in the mid-19th century across the rear of the main block and the east wing.

Also on the property are the contributing kitchen, office, and servant's quarters.

This article about a property in Orange County, North Carolina on the National Register of Historic Places is a stub.