[3] Francesco Antonio Zaccaria, writer and archaeologist, who died in 1795, was buried in the Chapel of St Ignatius of Loyola here.

The unusual interment has been linked to the case of Emanuela Orlandi's kidnapping and the tomb was opened for investigation in 2012.

[8] With the authorisation of the Italian judiciary in accordance with the desire expressed by the widow of De Pedis, on 18 June 2012, at the end of the further investigations carried out on the burial, the body of De Pedis was moved from the basilica of Sant'Apollinare and transferred to the Prima Porta Cemetery where it was cremated.

The high altar was made on orders from Pope Benedict XIV, with stucco decorations by Bernardino Ludovisi and an early 17th-century altarpiece depicting St Apollinaris' Consecration as Bishop of Ravenna by Ercole Graziani the Younger.

It contains a 1494 fresco of The Virgin, Queen of Apostles which, survived the Sack of Rome because the priests had covered it with a lime whitewash and was then rediscovered in 1645 when two boys and a soldier took refuge in the church during an earthquake.

The churchs nave features an inlaid marble pavement naming past cardinals, a tribute to its historical importance.

Elegant 18th-century confessionals are able to provide a spaces for private reflection while the organ, situated above the entrance on a grand gallery with curved wings, adds a rich musical element to the building.

[10] The 1748 dome, layered with stucco patterns based on a Greek cross, culminates in a lantern featuring a dove representing of the Holy Spirit.

[11] The church is composed of three main sections: a wedge-shaped entrance housing the icon of Our Lady, a nave with aisles that are divided into six chapels, and a presbyterium surrounded by a saucer dome lit with a lantern.

The nearby campanile has arched openings with a pyramidal top, while the adjoining palazzo includes a colonnaded courtyard and Baroque fountains, one by Bernini.